TABLE 3

Levels of covalently bound radioactivity in plasma

TimeCovalently Bound Radioactivity (Plasma Pellet)Total Radioactivity (Plasma)
Hourng⋅Eq/mlng⋅Eq/ml
0LOQa
0.5520
147549
1.5447
255364
3259
448195
6141
865135
12115
1698
246194
4860
722547
Cmax65549
Cmax % of TR12100
tmax81
AUC0–72 h34886820
AUC0–72 h % of TR51100
AUC0–24 h14143690
AUC0–24 h % of TR38100
  • AUC0–24 h, area under the concentration-time curve from time 0 to 24 hours; AUC0–72 h, area under the concentration-time curve from time 0 to 72 hours; Cmax, maximum concentration; LOQ, limit of quantification; tmax, time to reach the maximum concentration; TR, total radioactivity.

  • a LOQ: 36 ng⋅Eq/ml.