TABLE 2

Heterogeneity analysis of the investigated OATP transporter abundance levels in human liver tissue

The weighted means, coefficients of variation (CV), range, and heterogeneity analysis of the analyzed hepatic tissue OATP transporter abundance levels data in liver tissue, SCHH, and cryopreserved hepatocytes in suspension

	Mean	CV	Range	Range  of max/min	No.  of samples	Q	Degrees  of freedom	P value	I²	Heterogeneity	References
	fmol/μg protein	%	fmol/μg protein	fmol/μg  protein					%
Human liver tissue
OATP1B1	5.9	42.5	0.8–44.3	3.3–6.6	86	10.30	4	<0.05	61	Moderate	Balogh et al. (2012), Kimoto et al. (2012), Karlgren et al. (2012), Prasad et al. (2014), Vildhede et al. (2014)
OATP1B3	2.0	45.2	0.1–11.8	1.5–32	86	20.60	4	<0.001	81	High	Balogh et al. (2012), Kimoto et al. (2012), Karlgren et al. (2012), Prasad et al. (2014), Vildhede et al. (2014)
OATP2B1	1.9	39.8	0.6–5.4	1.5–7.5	86	26.64	4	<0.001	85	High	Balogh et al. (2012), Kimoto et al. (2012), Karlgren et al. (2012), Prasad et al. (2014), Vildhede et al. (2014)
Sandwich-cultured human hepatocytes
OATP1B1	5.8	51.5	2.4–11.3	4.7^{^a}	5	—	—	—	—	—	Kimoto et al. (2012), Bi et al. (2012)
OATP1B3	0.8	30.0	0.5–1.2	2.5^{^a}	5	—	—	—	—	—	Kimoto et al. (2012), Bi et al. (2012)
OATP2B1	1.0	16.0	0.8–1.2	1.5^{^a}	5	—	—	—	—	—	Kimoto et al. (2012), Bi et al. (2012)
Human cryopreserved hepatocytes in suspension
OATP1B1	4.2	24.1	0.2–7.0	3.0^{^a}	17	—	—	—	—	—	Kimoto et al. (2012), Prasad et al. (2014), Bi et al. (2012), Ji et al. (2012), Kunze et al. (2014)
OATP1B3	1.8	26.8	0.005–5.8	3.6^{^a}	17	—	—	—	—	—	Kimoto et al. (2012), Prasad et al. (2014), Bi et al. (2012), Ji et al. (2012), Kunze et al. (2014)
OATP2B1	1.6	28.3	0.022–4.1	3.6^{^a}	17	—	—	—	—	—	Kimoto et al. (2012), Prasad et al. (2014), Bi et al. (2012), Ji et al. (2012), Kunze et al. (2014)

—–, Not applicable
↵^a Based on data reported in Kimoto et al. (2012)