TABLE 3

Additional structural alert for P450 inactivation

Structural Alert ExampleReference
AlkeneSecobarbitalHe et al., 1996a,b
Alkyne17α-ethynylestradiol and erlotinibLin et al., 2002; Li et al., 2010
Hydrazine1-AminobenzotriazoleOrtiz de Montellano and Watanabe, 1987
CyclopropylamineN-(2-phenylcyclopropyl)amineBondon et al., 1989; Shaffer et al., 2002; Cerny and Hanzlik, 2005; Kalgutkar et al., 2007
DihaloalkaneChloramphenicol and halothanePohl et al., 1978; Orr et al., 2012
FuranMethoxsalen, bergamottin, 4-lpomeanolKoenigs and Trager, 1998; Lin et al., 2012; Orr et al., 2012
ThiopheneTienilic acid, ticlopidine, suprofenKoenigs et al., 1999; Orr et al., 2012
Phenol and aminophenolTrazodone, dasatinib, tacrineBaer et al., 2007; Hollenberg et al., 2008; Wen et al., 2009