Fitted estimates obtained with fitting the final model (Model H) to liver perfusion data (Table 4), with incorporation of nonlinear protein binding and nonlinear metabolism and biliary secretion of verapamil and norverapamil (see Appendix C for the mass balance equations)

↵^{a} The assigned parameters in the PBPK model for fitting of verapamil, preformed; and formed norverapamil simultaneously; from multiple indicator dilution studies in rat (Pang et al., 1988).

↵^{b} The ratio of intrinsic clearances is the same as the ratio of the hepatic clearance.