TABLE 1
Binding (k R→t) and debinding (k t→R) constants for verapamil and norverapmil to the tubing of the perfusion apparatus, obtained by fitting the perfusate data in the absence of a rat liver in sham-liver perfusion studies (Fig. 1)
| Drug | Debinding | Binding |
|---|---|---|
| µM | min−1 | min−1 |
| Verapamil (n = 3) |
|
|
| 1 | 0.0206 ± 0.0161 | 0.0083 ± 0.0012 |
| 50 | 0.0400 ± 0.0382 | 0.0052 ± 0.0041 |
| 100 | 0.0197 ± 0.0171 | 0.0032 ± 0.0023 |
| Norverapamil (n = 3) |
|
|
| 1.5 | 0.0156 ± 0.0013 | 0.0044 ± 0.0005 |
| 5 | 0.0047 ± 0.0063 | 0.0024 ± 0.0007 |