TABLE 3

Drug-specific parameters used for the prediction of absorption

Drugs	Dose	K_m,u		V_max		P_app,Caco-2	f_B	MW
	μmol	μM		μmol/h per pmol		cm/h
		CYP3A	P-gp	CYP3A	P-gp
Alfentanil	7220	22.8	NA	1.30	0	0.105	0.137	417
Alprazolam	1290	265	NA	0.238	0	0.0918	0.341	309
Buspirone	4150	7.98	NA	1.04	0	0.0914	0.062	386
Cisapride	16,100	3.20	NA	0.526	0	0.108	0.0200	466
Cyclosporin	474,000	1.40	0.0567	0.0333	1.38×10⁶	0.0286	0.0140	1203
Felodipine	26,000	5.31	NA	7.45	0	0.0151	0.068	384
Lovastatin	49,400	7.80	NA	22.8	0	0.0522	0.03	405
Midazolam	9200	3.31	NA	1.35	0	0.117	0.056	326
Nifedipine	28,900	11.0	NA	1.45	0	0.0846	0.066	346
Nisoldipine	12,900	2.10	NA	9.66	0	0.0720	0.003	388
Repaglinide	552	15.6	NA	0.442	0	0.0868	0.025	453
Rifabutin	177,000	10.9	NA	0.338	0	0.0342	0.483	847
Saquinavir	1,490,000	0.300	0.863	1.09	2.47×10⁶	0.0497	0.038	671
Sildenafil	52,600	15.0	NA	1.01	0	0.0922	0.063	475
Simvastatin	95,500	3.39	NA	14.2	0	0.0245	0.025	419
Trazodone	202,000	312	NA	4.41	0	0.0871	0.07	372
Triazolam	729	85.1	NA	0.261	0	0.101	0.161	343
Zolpidem	16,300	140	NA	0.185	0	0.115	0.105	307
Quinidine	615,000	4.00	0.348	0.00766	5.11×10⁶	0.0491	0.299	325
Verapamil	87,900	49.0	0.622	6.92	3.65×10⁶	0.0516	0.104	455