TABLE 1

Summary of the 137 drugs in five different categories

Category 1 (In Vitro Negative/In Vivo Negative; 48 Drugs)Category 2 (In Vitro Positive/In Vivo Negative; 18 Drugs)Category 3 (In Vitro Negative/In Vivo Positive; 10 Drugs)Category 4 (In Vitro Positive/In Vivo Positive; 26 Drugs)Unassigned (No In Vitro and/or In Vivo Inhibition Data; 35 Drugs)
Amphetamine (CYP2D6)Metoprolol (CYP2D6)Atomoxetine (CYP2D6)bAmiodarone (CYP2C9)Atazanavir(CYP2C8, CYP3A)AlendronateLamotrigine
Amitriptyline (CYP2C19 and CYP2D6)Mometasone (CYP2B6, CYP2C8)Budesonide (CYP3A)Amlodipine (CYP3A)Azithromycin (CYP3A)AlfuzosinLatanoprost
Anastrozole (CYP2C9)Moxifloxacin (CYP2B6)Diclofenac (CYP3A)Atorvastatin (CYP3A)Bicalutamide (CYP3A)BisoprololLevalbuterol
Aripiprazole (CYP2D6)Olanzapine (CYP1A2)Ezetimibe (CYP3A)Bupropion (CYP2D6)Celecoxib (CYP2D6)Darbepoetin alfaMeropenem
Bosentan (major P450s)aOlmesartan (CYP2C9)Fenofibrate (CYP2C8)Capecitabine (CYP2C9)Clopidogrel (CYP2B6)DesloratadineMetformin
Candesartan (CYP3A)Pemetrexed (CYP1A2, CYP2C9, CYP2D6, CYP3A)Fluticasone (CYP3A)Ciprofloxacin (CYP1A2)Cyclosporin (CYP3A)DonepezilOseltamivir
Carvedilol(CYP2B6, CYP2C8)Pioglitazone (CYP2C8)Irbesartan (CYP2C9)Escitalopram (CYP2D6)Diltiazem (CYP3A)DorzolamideRamipril
Cefdinir(CYP1A2, CYP2C19, CYP2D6, CYP3A)Pramipexole (CYP2D6)Lansoprazole (CYP2C19)Gemfibrozil (CYP2C8)Duloxetine (CYP2D6)DoxazosinRisedronate
Cetirizine (CYP3A)Pravastatin (CYP2C9)Levofloxacin (CYP2C9)Sertraline(CYP2D6, CYP3A)Efavirenz (CYP3A)cEnalaprilRivastigmine
Docetaxel (CYP3A)Pregabalin(major P450s)Montelukast (CYP2C8)Venlafaxine (CYP2D6)Erlotinib (CYP3A)EnoxaparinSevoflurane
Famotidine (CYP2C19, CYP2D6, CYP3A4)Quetiapine(major P450s)aOndansetron (CYP3A)Esomeprazole (CYP2C19)ErythropoietinSomatostatin
Fentanyl (CYP3A)Ranitidine (CYP1A2, CYP2C8, CYP2C9, CYP2D6, CYP3A)Pantoprazole (CYP2C19)Fluconazole(CYP2C9, CYP2C19, CYP3A)EstrogenSomatropin
Gabapentin(CYP2B6, CYP2C9, CYP2D6, CYP3A)Risperidone (CYP2D6)Rabeprazole (CYP2C9, CYP2C19)Fluoxetine(CYP2C19, CYP2D6)EszopicloneSumatriptan
Glimepiride (CYP2C9)Ropinirole (CYP1A2)Raloxifene (CYP2C9)Fluvastatin (CYP2C9)FexofenadineTemozolomide
Irinotecan (CYP3A)Rosuvastatin (CYP2C8)Rosiglitazone (CYP2C8)Imatinib (CYP3A)FilgrastimTeriparatide
Letrozole (CYP3A)Salmeterol (CYP2C8)Sildenafil (CYP3A)Lopinavir (CYP3A)FinasterideTiotropium
Levetiracetam (CYP3A, CYP2C9)Simvastatin (CYP3A)Tadalafil (CYP3A)Modafinil (CYP2C19)GoserelinValacyclovir
Levothyroxine (CYP2C8)Telmisartan (CYP2C9)Tamoxifen (CYP2D6)Nefazodone (CYP3A)Zoledronate
Lidocaine(CYP2D6, CYP3A)Thalidomide (CYP3A)Nifedipine (CYP3A)
Linezolid(major P450s)aTopiramate (CYP2C9)Omeprazole (CYP2C19)
Losartan (CYP2C9)Valsartan (CYP2C9)Oxcarbazepine (CYP2C19)
Meloxicam (CYP2C9)Vardenafil (CYP3A)Paroxetine (CYP2D6)
Memantine (CYP2D6)Ziprasidone (CYP2D6)Terbinafine (CYP2D6)
Mofetil (CYP3A)Zolpidem(CYP1A2, CYP2D6, CYP3A)Valproate (CYP2C9)
Voriconazole (CYP2B6, CYP2C8, CYP2C9, CYP3A)
Zileuton (CYP1A2)
  • a Major P450s: major drug metabolizing P450s (CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP3A4).

  • b Atomoxetine: category 1 for CYP3A substrates.

  • c Efavirenz induction masks in vivo inhibition.