PK parameter estimates following a single dose of mAb A in ADA-positive cynomolgus monkeys from the subcolony without pre-existing ADA
| Animal ID | Dose Group | Cmax | Tmax | AUCinf | Vz | CL | t1/2 |
|---|---|---|---|---|---|---|---|
| μg/ml | days | μg·day/ml | ml/kg | ml/day/kg | days | ||
| 705599 | 3 mg/kg i.v. | 78.57 | – | 565.93 | 43.92 | 5.30 | 5.74 |
| 707593 | 3 mg/kg s.c. | 16.25 | 7.00 | 510.13 | – | – | 13.01 |