TABLE 7

PK parameter estimates (mean ± S.D.) following a single subcutaneous dose of mAb A in cynomolgus monkeys from the subcolony without pre-existing ADA

Dose	N	C_max	T_max^{^a}	AUC_inf	t_1/2	F^{^b}
		μg/ml	days	μg·day/ml	days	%
3 mg/kg s.c.	5^{^c}	23.7 ± 8.01	3.00 (3.00–14.00)	625 ± 145	15.8 ± 0.97	93

↵^a Median (range) instead of mean ± S.D. is presented for the T_max.
↵^b F (%) was determined by mean AUC_inf of the 3-mg/kg i.v. and s.c. dose groups.
↵^c N = 4 for AUC_inf and t_1/2.