Dose | N | Cmax | AUCinf | DNAUCa | Vz | CL | t1/2 |
---|---|---|---|---|---|---|---|
μg/ml | μg·day/ml | μg·day/ml/mg/kg | ml/kg | ml/day/kg | days | ||
1 mg/kg i.v. | 4 | 23.0 ± 4.66 | 195 ± 19.5 | 195 ± 19.5 | 91.3 ± 8.43 | 5.16 ± 0.51 | 12.4 ± 1.66 |
3 mg/kg i.v. | 4b | 76.5 ± 2.66 | 675 ± 54.9 | 225 ± 18.3 | 90.9 ± 0.95 | 4.46 ± 0.37 | 14.2 ± 1.17 |
10 mg/kg i.v. | 4 | 219 ± 14.9 | 2676 ± 731 | 268 ± 73.2 | 86.1 ± 15.4 | 3.99 ± 1.24 | 15.6 ± 3.63 |
5 mg/kg i.v.c | 3 | 116 ± 14.6 | 1127 ± 240 | 225 ± 47.9 | 111 ± 31.9 | 4.59 ± 1.09 | 16.7 ± 0.82 |