Effects of IL-1β and IL-6 on metabolism enzymes mRNA expression in Hep:KC (1:0 and 1:0.4) cell cultures
Metabolism Enzymes | Exposure to IL-1β (6.25–5000 pg/ml), 4 Days | Exposure to IL-6 (6.25–5000 pg/ml), 4 Days | ||
---|---|---|---|---|
Effectsa | KC-Dependent Effects? | Effectsa | KC-Dependent Effects? | |
CYP1A1 | ↔ | — | ↔ | — |
CYP1A2 | ↓ | Yes | ↓ | — |
CYP2A6 | ND | — | ND | — |
CYP2B6 | ↔ | — | ↓ | — |
CYP2C8 | ↓ | Yes | ↓ | — |
CYP2C9 | ↓ | Yes | ↓ | — |
CYP2C9 | ↔ | — | ↔ | — |
CYP2C19 | ND | — | ↔ | — |
CYP2D6 | ↔ | — | ↔ | — |
CYP2E1 | ↔ | — | ↔ | — |
CYP3A4 | ↓ | Yes | ↓ | — |
GSTA1 | ↓b | Yes | ↓ | — |
GSTA2 | ↓b | Yes | ↓ | — |
SULT1A1 | ND | — | ND | — |
SULT1A2 | ND | — | ND | — |
UGT1A1 | ↓ | Yes | ↓ | — |
UGT2B7 | ↓b | Yes | ↓ | — |