Effects of IL-1β and IL-6 on acute-phase proteins mRNA expression in Hep:KC (1:0 and 1:0.4) cell cultures
| Proteins | Exposure to IL-1β (6.25–5000 pg/ml), 4 days | Exposure to IL-6 (6.25–5000 pg/ml), 4 days | ||
|---|---|---|---|---|
| Effectsa (Highest Observed % Untreated Control) | KC-Dependent Effects? | Effects (Highest Observed % Untreated Control) | KC-Dependent Effects? | |
| AAG | ↑ | Yes | ↑ | — |
| 1250 ± 94 (1:0) | 1986 ± 170 (1:0) | |||
| 1459 ± 412 (1:0.4) | 1024 ± 98 (1:0.4) | |||
| CRP | ↑ | Yes | ↑ | — |
| 1133 ± 260 (1:0) | 95,220 ± 12,671 (1:0) | |||
| 53,132 ± 15,568 (1:0.4) | 80,426 ± 25,395 (1:0.4) | |||
| SAA2 | ↑ | — | ↑ | — |
| 5057 ± 1181 (1:0) | 18,208 ± 6529 (1:0) | |||
| 5319 ± 1688 (1:0.4) | 10,392 ± 1643 (1:0.4) | |||
↵a Effects were noted as upregulation (↑) of ≥150% of untreated control in a concentration-dependent manner.