Mean dose-normalized Cmax and AUC0–last after an i.v. dose of PF-05231023 in rats and monkeys
| Dose (mg/kg) | n | Total IgG | Intact NT | Intact CT | |||
|---|---|---|---|---|---|---|---|
| Cmax/Dose | AUC0–72h/Dose | Cmax/Dose | AUC0–72h/Dose | Cmax/Dose | AUC0–72h/Dose | ||
| µg/ml | µg⋅h/ml | µg/ml | µg⋅h/ml | µg/ml | µg⋅h/ml | ||
| Rats | |||||||
| 0.1 | 3 | – | – | 32.5 | 424 | 32.4 | 147 |
| 1 | 5 | – | – | 27.9 | 436 | 27.3 | 121 |
| 100 | 6 | – | – | 25.7 | 348 | 26.9 | 116 |
| 300 | 6 | – | – | 26.4 | 383 | 25.9 | 138 |
| Monkeys | |||||||
| 5 | 6 | 23.4 | 406 | 25.2 | 428 | 25.0 | 84.2 |
| 20 | 6 | 24.4 | 396 | 28.8 | 372 | 25.0 | 86.0 |
| 100 | 6 | 25.0 | 403 | 24.8 | 343 | 24.1 | 103 |
| 300 | 6 | 18.8 | 407 | 21.9 | 420 | 21.2 | 123 |