Transporter | Km | Vmax | Vmax/Km | Vmax Ratioa | Intrinsic Transport Clearance Ratiob |
---|---|---|---|---|---|
µM | pmol/min/mg Total Protein | µL/min/mg Total Protein | % Relative to OAT2 | % Relative to OAT2 | |
OAT2 | 795 ± 138 | 24,987 ± 1,204 | 31.4 | 100 | 100 |
OCT2 | 18,771 ± 1,139 | 17,546 ± 739 | 0.93 | 64.7 | 2.7 |
MATE1 | 10,234 ± 339 | 1,058 ± 20 | 0.10 | 0.7 | 0.054 |
MATE2K | 21,597 ± 27,066 | 2,948 ± 3,477 | 0.14 | 34.3 | 1.3 |
↵a Vmax ratios are calculated as the ratios of creatinine uptake into transporter-expressing HEK cells, which are normalized to the expression of individual transporter proteins.
↵b Intrinsic transport clearance is determined by dividing the Vmax value by the Km value, which is normalized to the expression of individual transporter protein.