In vitro brain microdialysis recovery of eight compounds measured in discrete and cassette methods
Data are presented as the mean ± S.D. (n = 4).
| Compound | Recovery | ||
|---|---|---|---|
| Cassette, % | Discrete, % | Cassette/Discrete Ratio | |
| Carbamazepine | 28.8 ± 1.3 | 34.0 ± 1.8 | 0.8 |
| Citalopram | 26.4 ± 1.7 | 26.9 ± 2.1 | 1.0 |
| Desmethylclozapine | 32.0 ± 1.8 | 30.5 ± 4.0 | 1.0 |
| Diphenhydramine | 27.2 ± 1.8 | 26.4 ± 8.7 | 1.0 |
| Gabapentin | 22.5 ± 4.2 | 24.6 ± 4.7 | 0.9 |
| Metoclopramide | 23.7 ± 1.9 | 39.9 ± 2.4 | 0.8 |
| Naltrexone | 24.2 ± 1.5 | 19.8 ± 1.3 | 1.2 |
| Stavudine | 16.0 ± 2.5 | 19.0 ± 1.9 | 0.8 |
| Mean | NC | NC | 1.0 |
| S.D. | NC | NC | 0.1 |
NC, not calculated.