Chimeric mice used for analyses in the present study
| Animal Number | Sex of host mouse | No. of Transplanted Cells | Age at Sacrifice | Body Weight at Sacrifice | hAlb at Sacrifice | Expected RI from hAlb Levela |
|---|---|---|---|---|---|---|
| ×105 cells/mouse | weeks | grams | mg/ml | % | ||
| Cyp3aKO 2-3 | Male | 2.5 | 14 | 17.1 | 11.2 | 87 |
| Cyp3aKO 3-4 | 5.0 | 14 | 12.9 | 11.2 | 87 | |
| Cyp3aKO 3-6 | 5.0 | 14 | 12.9 | 15.7 | 97 | |
| Cyp3aKO 2-5 | Female | 2.5 | 14 | 14.8 | 5.4 | 64 |
| Cyp3aKO 2-10 | 2.5 | 14 | 14.0 | 11.0 | 86 | |
| Cyp3aKO 3-10 | 5.0 | 14 | 16.8 | 6.5 | 69 | |
| PXB 194-4 | Male | 2.5 | 15 | 21.8 | 11.5 | 88 |
| PXB 194-22 | 2.5 | 15 | 20.1 | 8.7 | 79 | |
| PXB 195-21 | 2.5 | 14 | 17.6 | 6.3 | 68 | |
| PXB 196-24 | Female | 2.5 | 14 | 14.0 | 12.2 | 89 |
| PXB 196-26 | 2.5 | 14 | 17.9 | 9.1 | 80 | |
| PXB 196-29 | 2.5 | 14 | 14.8 | 13.2 | 92 |
↵a Expected RI from hAlb level was calculated by the formula: y = 733927e0.0314x, where x = expected RI, y = hAlb.