Donor | Host Mouse | No. of Transplanted Cells/Mouse | Sex of Host Mouse | No. of Transplanted Mice | No. of Dead Mice until 12 Weeks Old | No. of Mice at 12 Weeks Olda | Body Weight at 12 Weeks Old | hAlb at 12 Weeks Old | Portion of Chimeric Mice with RI > 70% |
---|---|---|---|---|---|---|---|---|---|
×105 cells | grams | mg/ml | % | ||||||
BD85 | Cyp3aKO/uPA/SCID | 2.5 | Male | 8 | 0 | 8 | 16.7 ± 3.6 | 4.0 ± 3.1 | 15.0 |
Female | 12 | 1 | 11 | 14.3 ± 2.3 | 3.2 ± 2.7 | ||||
3.5 | Male | 6 | 1 | 3 | 14.8 ± 0.8 | 8.5 ± 6.3 | 53.3 | ||
Female | 9 | 2 | 5 | 13.4 ± 2.2 | 8.5 ± 3.7 | ||||
5.0 | Male | 22 | 2 | 20 | 14.7 ± 2.9 | 11.7 ± 2.7 | 77.8 | ||
Female | 23 | 0 | 22 | 12.6 ± 2.5 | 8.9 ± 5.4 | ||||
uPA/SCID | 2.5 | Male | 212 | 23 | 158 | 16.3 ± 3.1 | 10.0 ± 3.0 | 72.9 | |
Female | 43 | 1 | 39 | 15.7 ± 2.5 | 8.6 ± 2.7 | ||||
BD195 | Cyp3aKO/uPA/SCID | 2.5 | Male | 110 | 4 | 57 | 18.1 ± 2.6 | 8.1 ± 4.0 | 65.1 |
Female | 19 | 0 | 18 | 16.5 ± 1.9 | 6.9 ± 3.0 | ||||
3.0 | Male | 23 | 0 | 23 | 15.3 ± 2.7 | 10.6 ± 2.8 | 82.6 |
↵a Number of mice that were alive and unused for other studies at 12 weeks old.
Data of body weight and hAlb at 12 weeks old are shown as mean 6 S.D.