Formation of metabolites from BBR by recombinant human CYP isozymes (nmol/nmol P450)
Each value represents the mean of three samples ± S.D.
| System | 6-OH-BBR | CAT | DBH |
|---|---|---|---|
| CYP1A1 | 23.9 ± 2.08 | 0.75 ± 0.02 | ND |
| CYP1A2 | ND | ND | ND |
| CYP2B6 | ND | ND | ND |
| CYP2C8 | 60.4 ± 3.3 | ND | ND |
| CYP2C9 | 398 ± 10 | ND | 0.15 ± 0.02 |
| CYP2C19 | 193 ± 33 | ND | ND |
| CYP2D6 | 15.3 ± 1.2 | 1.13 ± 0.07 | ND |
| CYP2E1 | ND | 0.66 ± 0.07 | ND |
| CYP3A4 | ND | 0.88 ± 0.00 | ND |
ND, not detected.