Percentage of unbound fraction in plasma and brain homogenate for three species
Data are presented as means ± S.D.
ND, not determined.
↵a Stock solutions of test compounds were added to plasma to give final concentrations of 0.1% DMSO and 1 μM compound.
↵b Brain homogenate was prepared in 100 mM phosphate buffer (1:3 w/v; pH 7.4) by probe sonication.