TABLE 3

Loperamide dose proportionality values

Values are expressed as slope of the regression of AUC0–last versus dose for each loperamide dose analyzed by 3D versus 4D, IVM sensitivity/nonsensitivity, or genotype/phenotype grouping.

GroupMeanStdevnSignificant 
Diff*P Value
4Ds250.20177.16233Ds v 4Ds0.012
3Ds515.90398.1410
WT198.0171.737WT v Mut0.013
HNS284.32214.109
HS239.48106.477
Mut529.24414.8110
IVMNS246.56168.7016
IVMS409.93350.2117
  • * P values are shown only for group comparisons with statistically significant differences. All group comparisons were calculated.