TABLE 5

Clinical signs of loperamide CNS toxicity observed in IVM-nonsensitive and IVM-sensitive Collies

Compilation of the clinical signs in all Collies across all dose groups.

GroupClinical SignNo. of Collies
IVM-nonsensitive ColliesAtaxia1
Salivation8
Depression0
Mydriasis4
IVM-sensitive ColliesAtaxia10
Salivation13
Depression6
Mydriasis11