Group | Group Size | Gender Ratio | Weight* | Age* | IVM Sensitivitya | 3Db or 4D Collies |
---|---|---|---|---|---|---|
M/F | kg | years | per group | |||
Wild-Type | 7 | 4/3 | 26.4 ± 1.2 | 3.6 ± 0.7 | 0/7 | 0/7 |
Heterozygous Non-IVM-Sensitive | 9 | 2/7 | 28.4 ± 1.9 | 4.3 ± 0.9 | 0/9 | 1/8 |
Heterozygous IVM-Sensitive | 7 | 3/4 | 26.1 ± 1.8 | 3.8 ± 0.7 | 7/7 | 3/4 |
Homozygous Mutant | 10 | 5/5 | 27.1 ± 1.5 | 4.0 ± 0.4 | 10/10 | 6/4 |
↵* Mean ± S.E.M.
↵a Number of Collies in group showing central nervous system toxicities following IVM administration (0.1 mg/kg by mouth) out of total number per group.
↵b Collies that received either three doses of loperamide (3D) or all four doses of loperamide (4D). The 3D group received the 0.01 mg/kg, 0.05 mg/kg, and 0.10 mg/kg doses of loperamide. The 4D group received all four doses of loperamide; 0.01 mg/kg, 0.05 mg/kg, 0.10 mg/kg and 0.20 mg/kg.