TABLE 1

Collie group size, ages, and weights

The ABCB1 genotype and the IVM sensitivity (phenotype) of the Collies were known prior to enrollment in the study.

GroupGroup SizeGender Ratio Weight*Age*IVM Sensitivitya3Db or 4D Collies
M/Fkgyearsper group
Wild-Type74/326.4 ± 1.23.6 ± 0.70/70/7
Heterozygous 
Non-IVM-Sensitive92/728.4 ± 1.94.3 ± 0.90/91/8
Heterozygous 
IVM-Sensitive73/426.1 ± 1.83.8 ± 0.77/73/4
Homozygous Mutant105/527.1 ± 1.54.0 ± 0.410/106/4
  • * Mean ± S.E.M.

  • a Number of Collies in group showing central nervous system toxicities following IVM administration (0.1 mg/kg by mouth) out of total number per group.

  • b Collies that received either three doses of loperamide (3D) or all four doses of loperamide (4D). The 3D group received the 0.01 mg/kg, 0.05 mg/kg, and 0.10 mg/kg doses of loperamide. The 4D group received all four doses of loperamide; 0.01 mg/kg, 0.05 mg/kg, 0.10 mg/kg and 0.20 mg/kg.