TABLE 2

AUC0–last values for each loperamide dose analyzed by 3D versus 4D, IVM sensitivity/nonsensitivity, or genotype/phenotype grouping

DoseGroupMeanStdevn% CVSignificant Diff*P Value
0.014Ds2.610.982237.553Ds vs 4Ds0.0066
3Ds4.131.761042.62
WT2.340.50621.37
HNS2.610.72927.47
HS3.491.44741.26
Mut3.672.011054.77
IVMNS2.590.641524.71
IVMS3.591.751748.75
0.054Ds12.215.382344.06
3Ds17.309.801056.65
WT10.603.89736.70
HNS14.194.74933.40
HS10.955.11746.67
Mut17.5210.371059.19
IVMNS12.624.631636.69
IVMS14.829.091761.34
0.14Ds20.776.622331.873Ds vs 4Ds0.0004
3Ds50.9038.76976.15
WT18.986.70735.30Mut vs WT0.0309
HNS29.0319.64967.65
HS20.936.58631.44
Mut41.6037.431089.98
IVMNS24.6315.821764.23
IVMS33.8531.011591.61
0.24Ds50.5034.032367.39Not available
3Ds0
WT40.5513.68733.74HNS vs Mut0.0469
HNS46.4913.52929.08HS vs Mut0.0186
HS35.159.20326.17
Mut88.4571.70481.06
IVMNS43.8913.461630.67
IVMS65.6158.40789.01
  • * P values are shown only for group comparisons with statistically significant differences. All group comparisons were calculated.