TABLE 2

Catalytic activities by recombinant marmoset P450 2C enzymes

Drug Oxidation	Substrate Concentration	Catalytic Activities
Drug Oxidation	Substrate Concentration	2C8	2C18	2C19	2C58	2C76
	µM	min⁻¹	min⁻¹	min⁻¹	min⁻¹	min⁻¹
Ethoxyresorufin O-deethylation	10	0.06	0.19	0.45	0.52	0.05
7-Ethoxycoumarin O-deethylation	100	0.20	0.06	0.31	0.65	0.01
Coumarin 7-hydroxylation	100	0.002	<0.001	<0.001	0.013	<0.001
7-Pentoxyresorufin O-deethylation	10	0.06	0.11	0.17	0.18	0.02
Paclitaxel 6α-hydroxylation	100	1.0	<0.5	<0.5	<0.5	<0.5
Diclofenac 4′-hydroxylation	100	<0.0001	0.001	0.002	<0.0001	0.001
Tolbutamide methyl hydroxylation	2500	62	0.25	19	0.34	0.17
Flurbiprofen 4-hydroxylation	100	0.54	<0.01	4.7	0.42	<0.01
Racemic warfarin 7-hydroxylation	100	<0.0001	0.0023	0.037	<0.0001	<0.0001
S-warfarin 7-hydroxylation	100	<0.0001	0.0056	0.17	<0.0001	<0.0001
R-warfarin 7-hydroxylation	100	<0.0001	0.0028	0.0053	<0.0001	<0.0001
Omeprazole 5-hydroxylation	100	<0.01	<0.01	50	<0.01	<0.01
Chlorzoxazone 6-hydroxylation	500	0.96	<0.05	<0.05	1.6	<0.05
Bufuralol 1′-hydroxylation	100	1.5	0.73	10	6.2	<0.01
Midazolam 1′-hydroxylation	100	<0.3	<0.3	<0.3	<0.3	<0.3