Clinically observed and PBPK model–predicted pharmacokinetic parameters of crizotinib in healthy subjects following a single intravenous or oral administration of crizotinib
Data are expressed as geometric mean with percent coefficient of variation (CV%) in parentheses (n = 14 for the observed; n = 15 per group × 6 groups for the predicted).
| Single Intravenous Infusion (50 mg) | Single Oral Administration (250 mg) | |||||
|---|---|---|---|---|---|---|
| Cmax | AUC0–∞ | t1/2 | Cmax | AUC0–∞ | t1/2 | |
| ng/ml | ng⋅h/ml | h | ng/ml | ng⋅h/ml | h | |
| Observed | 155 (19) | 1067 (18) | 39 (16) | 100 (28) | 2321 (34) | 29 (10) |
| Predicted | 167 (11) | 1258 (23) | 45 (19) | 103 (34) | 2878 (47) | 58 (24) |
| P/Oa | 1.1 | 1.2 | 1.2 | 1.0 | 1.2 | 2.0 |
↵a Ratio of the predicted to observed results.