TABLE 1

Changes of serum bile acids after a single intravenous dose of 100 mg/kg of TAK-875 to Sprague-Dawley rats (each group n = 6)

	BA type	Control			TAK-875
No.	(ng/ml)	Predose	1 hour Postdose	Fold	Predose	1 hour Postdose	Fold
1	CA^{^a}	32,508 ± 16,453	27,242 ± 16,670	0.870 ± 0.358	22,973 ± 10,926	74,797 ± 19,259	2.94 ± 0.50
2	DCA	2796 ± 1386	2650 ± 1140	0.985 ± 0.350	1891 ± 803	3308 ± 1050	1.85 ± 0.43
3	UDCA^{^a}	6654 ± 2715	5591 ± 2917	0.846 ± 0.295	5710 ± 2844	14,661 ± 4748	2.80 ± 0.67
4	LCA	33.7 ± 13.3	25.0 ± 5.1	0.798 ± 0.209	30.8 ± 12.3	25.6 ± 6.8	0.876 ± 0.155
5	GCA	1700 ± 780	1156 ± 614	0.713 ± 0.298	1148 ± 1035	1335 ± 1119	1.30 ± 0.70
6	CDCA	4355 ± 863	3590 ± 1188	0.923 ± 0.450	4946 ± 2988	5633 ± 3218	1.24 ± 0.35
7	GDCA	415 ± 167	303 ± 141	0.742 ± 0.198	270 ± 151	269 ± 177	1.02 ± 0.45
8	GCDCA	127 ± 57	94 ± 47	0.794 ± 0.301	139 ± 83	181 ± 106	1.43 ± 0.71
9	GUDCA	471 ± 201	362 ± 286	0.754 ± 0.337	330 ± 192	404 ± 232	1.46 ± 0.82
10	TCDCA^{^a}	79 ± 24	110 ± 35	1.40 ± 0.31	99 ± 40	281 ± 137	2.87 ± 0.62
11	TCA^{^a}	238 ± 105	337 ± 137	1.45 ± 0.33	289 ± 175	635 ± 274	2.17 ± 0.85

↵^a Indicates >2-fold increase at 1 hour postdose compared with the predose.