TABLE 1

Values used for model simulations and resulting predicted steady-state rosuvastatin concentrations and partitioning

Clearance parameters were scaled from those determined in the in vitro model to represent those in the liver of a 5-kg monkey. Volumes for the extracellular and intracellular compartments were fixed to those of the plasma and liver, respectively, of a 5-kg monkey. Extracellular and intracellular fu were fixed to those measured in monkey plasma and liver, respectively. The initial condition for C_EC and C_IC was arbitrarily fixed to 1 and 0 µM, respectively.

	PS_diff	Cl_up	fu_EC	fu_IC	C_EC	C_IC	Kp	Kp_u,u
	ml/min	ml/min			µM	µM
Scaled in vitro model parameters	82	1010	0.12	0.12	0.11	1.4	12	12
Corrected for transporter expression	82	1147	0.12	0.12	0.10	1.5	15	15
Corrected for cell surface area	14	1010	0.12	0.12	0.011	1.6	74	74
Active uptake not limited by binding	82	1010	0.12^{^a}	0.12	0.015	1.6	106	106

EC = extracellular; IC = intracellular.
↵^a Removed from Cl_up.