Migration and glucuronidation rate of carboxylic acid–containing drugs
Samples were prepared in triplicate; the values represent mean ± S.D. (n = 3).
| Test Compound | Migration Rate | Glucuronidation Rate | Half-Life of 1-O-β-AGa |
|---|---|---|---|
| % | % | hours | |
| Valproic acid | 0.3 ± 0.1 | 11.4 ± 0.4 | 79.0 (Fenselau, 1994) |
| Gemfibrozil | 0.5 ± 0.2 | 42.3 ± 4.8 | 71.4 (Sawamura et al., 2010) |
| Telmisartan | 0.3 ± 0.0 | 0.5 ± 0.2 | 45.6 (Sawamura et al., 2010) |
| Montelukast | 6.8 ± 0.5 | 0.3 ± 0.1 | 37.5 (Sawamura et al., 2010) |
| Meclofenamate | 3.5 ± 0.6 | 29.4 ± 1.6 | 28.1 (Sawamura et al., 2010) |
| Mefenamic acid | 5.6 ± 0.4 | 48.6 ± 3.8 | 17.0 (Sawamura et al., 2010) |
| Levofloxacin | NA | 0.0 ± 0.0 | 16.1 (Sawamura et al., 2010) |
| Repaglinide | 3.3 ± 0.1 | 8.7 ± 0.2 | 11.5 (Sawamura et al., 2010) |
| Clofibric acid | 13.1 ± 1.2 | 1.8 ± 0.9 | 7.3 (Fenselau, 1994) |
| Flufenamic acid | 10.6 ± 0.6 | 9.7 ± 1.6 | 7.2 (Sawamura et al., 2010) |
| Furosemide | 0.0 ± 0.0 | 0.7 ± 0.1 | 3.2 (Sawamura et al., 2010) |
| Ibuprofen | 40.3 ± 2.2 | 10.7 ± 1.0 | 2.7 (Sawamura et al., 2010) |
| S-Naproxen | 11.7 ± 2.1 | 80.1 ± 2.0 | 2.2 (Sawamura et al., 2010) |
| Indomethacin | 9.8 ± 0.5 | 22.0 ± 1.6 | 1.7 (Sawamura et al., 2010) |
| R-Naproxen | 27.2 ± 3.5 | 79.2 ± 2.1 | 1.1 (Sawamura et al., 2010) |
| (RS)-Benoxaprofen | 42.3 ± 0.6 | 18.7 ± 0.5 | 1.05b (Sawamura et al., 2010) |
| Dabigatran | NA | 0.0 ± 0.0 | 1.0 (Ebner et al., 2010) |
| Ibufenac | 50.9 ± 3.1 | 5.2 ± 0.3 | 0.8 (Sawamura et al., 2010) |
| Diclofenac | 98.1 ± 0.2 | 18.5 ± 3.8 | 0.7 (Sawamura et al., 2010) |
| Diflunisal | 25.2 ± 5.1 | 0.2 ± 0.0 | 0.67 (Williams and Dickinson, 1994) |
| Tolmetin | 54.9 ± 0.8 | 0.5 ± 0.0 | 0.4 (Sawamura et al., 2010) |
| Zomepirac | 61.9 ± 0.2 | 0.9 ± 0.0 | 0.4 (Sawamura et al., 2010) |
| Probenecid | 76.3 ± 0.4 | 0.5 ± 0.0 | 0.3 (Sawamura et al., 2010) |