Samples | t1/2 | Cmax | Tmax | AUC0–∞ | MRT |
---|---|---|---|---|---|
(h) | (µg/ml or µg/g tissue) | (h) | (h▪µg/ml or h▪µg/g tissue) | (h) | |
FF | |||||
Plasma | N.A. | N.A. | N.A. | N.A. | N.A. |
Skin | N.A. | N.A. | N.A. | N.A. | N.A. |
Eye | N.A. | N.A. | N.A. | N.A. | N.A. |
FA | |||||
Plasma | 6.4 ± 0.40 | 6.3 ± 1.1 | 9.7 ± 1.1 | 97 ± 14 | 13 ± 0.70 |
Skin | 11 ± 1.5 | 0.34 ± 0.017 | 13 ± 3.9 | 8.5 ± 1.3 | 20 ± 2.1 |
Eye | 22 ± 6.9 | 0.10 ± 0.0055 | 6.0 ± 1.4 | 2.6 ± 0.33 | 34 ± 10 |
RFA | |||||
Plasma | 12 ± 1.0 | 1.6 ± 0.10 | 12 ± 0.0 | 33 ± 3.2 | 21 ± 1.5 |
Skin | 17 ± 3.3 | 0.080 ± 0.0067 | 16 ± 4.7 | 2.0 ± 0.60 | 30 ± 4.2 |
Eye | N.A. | N.A. | N.A. | N.A. | N.A. |
AUC0-∞, area under the concentration vs. time curve from t=0 to t=∞ after administration; Cmax, maximum concentration; t1/2, terminal half-life; Tmax, time to maximum concentration; and MRT, mean residence time. Each value represents the mean±SEM for 4–7 rats. N.A., not available due to concentrations below the limit of detection.