Mean pharmacokinetic parameters FST-Fc, MV9, and MV12 in SCID mice after a single 10 mg/kg subcutaneous administration
The plasma concentrations were determined using validated antigen capture ELISAs. Pharmacokinetic parameters were determined from a non-compartmental analysis model. Values in parentheses represent the S.E.M. as calculated by the sparse sampling method used to extract PK parameters.
| Protein | Cmax | Tmax | AUC0–last |
|---|---|---|---|
| μg/ml | H | μg•h/ml | |
| FST-Fc | 11.3 (0.7) | 24 | 1092 (38) |
| MV9 | 10.7 (1.2) | 24 | 1347 (57) |
| MV12 | 36.5 (4.3) | 12 | 2940 (77) |
AUC0–last, area under the serum concentration curve from 0 to last concentration versus time point; Cmax, maximal observed serum concentration; Tmax, time at which maximal serum concentration was observed.