TABLE 1

The effect of compounds on the retinal and brain uptake index for [³H]pravastatin in wild-type rats

[³H]Pravastatin (10 µCi/rat), with [¹⁴C]n-butanol (0.1 µCi/rat) as the highly diffusible reference, injected into the carotid artery in the absence (control) and presence of inhibitors. Values represent means ± S.E. (n = 3 or 4 rats).

Inhibitor Pravastatin	Uptake Index (%)		Percentage of Control (%)
Inhibitor Pravastatin	Retina	Brain	Retina	Brain
Control	2.58 ± 0.52	0.485 ± 0.031	100.0 ± 20.3	100.0 ± 6.3
40 mM Pravastatin	1.38 ± 0.22^*	0.263 ± 0.024**	53.4 ± 8.4	54.2 ± 5.0
0.01 mM Digoxin	1.20 ± 0.24^*	0.224 ± 0.024**	46.6 ± 9.2	46.1 ± 4.9
0.3 mM E17βG	1.21 ± 0.16^*	0.361 ± 0.079	46.8 ± 6.1	74.5 ± 16.2
1 mM Probenecid	1.36 ± 0.14^*	0.204 ± 0.025**	52.8 ± 5.4	42.1 ± 5.2

↵* P < 0.05 and **P < 0.01, significantly different from the control. E17βG, estradiol 17-β glucuronide.