TABLE 4

Pharmacokinetic parameters FST-ΔHBS-Fc sialic acid variants in ASPGR-1 knockout mice after a single 10 mg/kg intravenous administration

Plasma concentrations were determined using validated antigen capture ELISAs. Pharmacokinetic parameters were determined from a linear trapezoidal with linear interpolation non-compartmental analysis model. Values in parentheses represent the S.E.M. as calculated by the sparse sampling analyses.

FST-ΔHBS-Fc VariantCmaxAUC0–lastAUC0–∞CL
μg/mlμg•h/mlμg•h/mlml/h/kg
MV9 16% SA98 (23)3369 (298)43432.3
MV9 60% SA136 (16)7131 (577)72481.4
  • AUC0–last, area under the serum concentration curve from 0 to last concentration versus time point; AUC0–∞, area under the serum concentration curve from time zero extrapolated to infinite time; CL, clearance; Cmax, maximal observed serum concentration.