TABLE 2

Metabolic capacity assessment of human hepatocyte preparations

Hepatocyte Preparation	Phenacetin O-Deethylase (CYP1A2)^{^a}	Tolbutamide-Hydroxylase (CYP2C9)^{^a}	Dextromethorphan O-Demethylase (CYP2D6)^{^a}	Midazolam 1ʹ-Hydroxylase (CYP3A)^{^a}
CD-Hu4237	0.169	0.005	0.233	0.428
BD-295	0.171	0.027	0.896	0.536
IVT-IBG	0.551	0.057	2.003	0.764
BD-281	0.894	0.066	ND	1.002
CD-Hu8084	0.182	0.088	0.286	0.167
HH1024	1.175	0.090	0.840	0.640
Reference historical data
n	82	83	100	85
Mean ± S.D.	0.978 ± 0.782	0.055 ± 0.035	0.812 ± 0.787	0.746 ± 0.597