TABLE 2

Pharmacokinetic parameters and statistics derived from fitting of each of three pharmacokinetic models (Fig. 1A) to the average data

Data presented as estimated values ± S.D.

Parameter	Control	VSD	ASD
One-compartment
V (ml/kg)	84.2 ± 8.3	67.3 ± 6.9	61.7 ± 7.11
K₁₀ (1/min)	0.10 ± 0.02	0.12 ± 0.02	0.13 ± 0.02
AIC	86.6	87.1	88.2
Two-compartment^{^a}
V_c (ml/kg)	57.2 ± 6.23	54.7 ± 4.98	52.8 ± 5.92
K₁₀ (1/min)	0.12 ± 0.01	0.12 ± 0.01	0.12 ± 0.01
K₁₂ (1/min)	0.25 ± 0.02	0.16 ± 0.01	0.15 ± 0.02
K₂₁ (1/min)	0.25 ± 0.03	0.17 ± 0.02	0.14 ± 0.02
AIC	61.2	59.7	62.6
A modified model^{^b}
V_c (ml/kg)	50.1 ± 2.18	48.9 ± 2.17	47.2 ± 2.11
K₁₀ (1/min)	0.09 ± 0.01	0.08 ± 0.01	0.08 ± 0.01
K₂₀ (1/min)	0.04 ± 0.01	0.04 ± 0.02	0.04 ± 0.02
K₁₂ (1/min)	0.23 ± 0.01	0.17 ± 0.01	0.15 ± 0.01
K₂₁ (1/min)	0.24 ± 0.01	0.16 ± 0.01	0.15 ± 0.01
AIC	49.6	48.3	50.1

↵^a Two-compartment model with drug elimination from central compartment.
↵^b Two-compartment model with drug elimination from both central and peripheral compartment.