Parameter | Cobimetinib1 | Total Plasma Radioactivity | Total Blood Radioactivity |
---|---|---|---|
Cmax (ng-Eq/ml) | 10.0 (2.70) | 68.2 (9.67) | 54.9 (5.20) |
tmax (h) | 4.02 (1.00, 8.00) | 2.00 (2.00, 2.05) | 2.00 (2.00, 2.05) |
AUC0–t (ng-Eq·h/ml) | 455 (179) | 3533 (812) | 2925 (497) |
AUC0–∞ (ng-Eq·h/ml) | 495 (183) | 4621 (1256) | 4012 (759)2 |
t1/2 | 75.5 (21.9) | 141 (56.9) | 97.9 (32.1)2 |