Pharmacokinetic parameters of donepezil after intravenous bolus administration with and without cilostazol or elacridar in female rats
Cilostazol (100 mg/kg or 500 mg/kg) dissolved in 0.5% methylcellulose was administered orally to female rats 30 minutes before intravenous administration of donepezil (1 mg/kg). Elacridar (1 mg/kg) dissolved in 5% DMSO was simultaneously administered with donepezil intravenously, and DMSO was also similarly administered in control experiments. Each experiment was repeated 3 times, and the mean values of pharmacokinetic parameters are shown with the S.D. (n = 3).
| Parameters | AUC (μg∣h/l) | Vd (l/kg) | CLtot (l/h/kg) |
|---|---|---|---|
| Control | 231 ± 25.0 | 12.0 ± 1.83 | 4.36 ± 0.50 |
| + Cilostazol (100 mg/kg) | 176 ± 44.9 | 12.3 ± 6.22 | 5.92 ± 1.47 |
| + Cilostazol (500 mg/kg) | 234 ± 15.9 | 10.8 ± 1.00 | 4.28 ± 0.29 |
| Control (5% DMSO) | 257 ± 81.8 | 17.5 ± 2.83 | 4.07 ± 1.33 |
| + Elacridar (5% DMSO) | 200 ± 17.2 | 18.2 ± 2.63 | 5.03 ± 0.45 |