TABLE 1 Pharmacokinetic parameters of donepezil after intravenous bolus administration with and without cilostazol or elacridar in female rats
Cilostazol (100 mg/kg or 500 mg/kg) dissolved in 0.5% methylcellulose was administered orally to female rats 30 minutes before intravenous administration of donepezil (1 mg/kg). Elacridar (1 mg/kg) dissolved in 5% DMSO was simultaneously administered with donepezil intravenously, and DMSO was also similarly administered in control experiments. Each experiment was repeated 3 times, and the mean values of pharmacokinetic parameters are shown with the S.D. (n = 3).