CLin vivoa | CLint,in vivob | fuBc | RBd | Suspended CLinte | Suspended CLh | Relay Method CLintg | Relay Method CLh | Plated CLinth | Plated CLh | HepatoPac Clinti | HepatoPac CLh | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
With Bindingf | Without Bindingf | With Bindingf | Without Bindingf | With Bindingf | Without Bindingf | With Bindingf | Without Bindingf | |||||||||
ml/min/kg | ml/min/kg | |||||||||||||||
Alprazolam | 0.591 | 1.6 | 0.381 | 0.761 | 2.1 | 0.77 | 1.9 | — | — | — | — | — | — | 4.0 | 1.4 | 3.3 |
Antipyrine | 0.572 | 0.60 | 0.972 | — | 0.67 | 0.63 | 0.65 | 1.3 | 1.2 | 1.2 | — | — | — | — | — | — |
Atazanavir | 8.71 | 108 | 0.141 | 1.01 | — | — | — | — | — | — | — | — | — | 142.3 | 10.2 | 18.1 |
Atomoxetine | 3.91 | 205 | 0.0241 | 0.551 | — | — | — | — | — | — | — | — | — | 70.9 | 1.5 | 16.0 |
Diazepam | 0.381 | 18.3 | 0.0211 | 0.711 | 6.6 | 0.14 | 5.0 | 15.0 | 0.31 | 8.7 | 2.81 | 0.06 | 2.5 | 12.2 | 0.26 | 7.7 |
Diclofenac | 4.21 | 583 | 0.0091 | 0.551 | 86.8 | 0.76 | 16.7 | — | — | — | 294.0 | 2.4 | 19.3 | |||
Disopyramide | 0.93 | 6.3 | 0.153 | 1.22 | — | — | — | 4.8 | 0.70 | 3.9 | — | — | — | — | — | — |
Flecanide | 9.11 | 37.1 | 0.441 | 0.891 | — | — | — | — | — | — | — | — | — | 2.5 | 1.1 | 2.3 |
Glimepiride | 0.621 | 70.3 | 0.0091 | 0.551 | 9.4 | 0.09 | 6.5 | — | — | — | — | — | — | 72.2 | 0.64 | 16.1 |
Ketoprofen | 1.22 | 74.9 | 0.0172 | — | 11.0 | 0.19 | 7.2 | 17.0 | 0.29 | 9.3 | — | — | — | — | — | — |
Lidocaine | 9.21 | 46.4 | 0.361 | 0.841 | 15.3 | 4.3 | 8.8 | — | — | — | — | — | — | 29.1 | 6.9 | 12.1 |
Meloxicam | 0.151 | 30.7 | 0.0051 | 1.22 1 | — | — | — | — | — | — | — | — | — | 4.6 | 0.02 | 3.8 |
Metroprolol | 13.32 | 46.5 | 0.802 | — | 5.3 | 3.5 | 4.2 | — | — | — | — | — | — | — | — | — |
Midazolam | 4.61 | 204 | 0.0292 | 0.691 | 138 | 3.4 | 18.0 | — | — | — | 58.22 | 1.6 | 15.3 | 238.4 | 5.2 | 19.0 |
Naproxen | 0.111 | 6.1 | 0.0182 | — | 1.4 | 0.03 | 1.3 | 18.0 | 0.32 | 9.6 | — | — | — | — | — | — |
Prednisolone | 2.42 | 9.7 | 0.281 | 1.01 | 30 | 6.0 | 12.2 | — | — | — | 6.7 | 1.7 | 5.1 | |||
Ranitidine | 2.92 | 4.4 | 0.772 | — | 3.0 | 2.1 | 2.6 | 3.1 | 2.1 | 2.7 | — | — | — | — | — | — |
Riluzole | 3.51 | 361 | 0.0121 | 1.71 | — | — | — | — | — | — | — | — | — | 96.0 | 1.1 | 17.0 |
Risperidone | 3.61 | 26.2 | 0.161 | 0.671 | — | — | — | — | — | — | — | — | — | 34.1 | 4.4 | 12.9 |
Theophylline | 1.11 | 2.3 | 0.481 | 0.851 | 2.6 | 1.2 | 2.3 | 2.8 | 1.3 | 2.5 | — | — | — | 3.2 | 1.4 | 2.8 |
Timolol | 112 | 48.9 | 0.482 | — | 4.4 | 1.9 | 3.6 | 14.0 | 5.1 | 8.4 | — | — | — | — | — | — |
Tolbutamide | 0.171 | 1.6 | 0.111 | 0.551 | 0.38 | 0.04 | 0.37 | 7.4 | 0.75 | 5.5 | 1.11 | 0.12 | 1.1 | 4.6 | 0.47 | 3.8 |
Verapamil | 13.32 | 310 | 0.122 | — | 33.4 | 3.4 | 12.8 | — | — | — | — | — | — | — | — | — |
Voriconazole | 3.81 | 11.1 | 0.421 | 1.03 | — | — | — | — | — | — | — | — | — | 25.3 | 7.0 | 11.4 |
Warfarin | 0.0451 | 2.5 | 0.0181 | 0.551 | — | — | — | 4.2 | 0.08 | 3.5 | — | — | — | 3.6 | 0.06 | 3.0 |
Zolmitriptan | 6.71 | 13.01 | 0.754 | 1.01 | — | — | — | 3.5 | 2.3 | 3.0 | — | — | — | — | — | — |
Zolpidem | 4.32 | 31.9 | 0.172 | — | 8.0 | 1.3 | 5.8 | — | — | — | — | — | — | — | — | — |
↵a The superscript numbers represent the following references: 1, Chan et al. (2013); 2, Hallifax et al. (2010); 3, Di et al. (2012).
↵b Clint in vivo back-calculated from Cltotal using eq. 3, except for zolmitriptan; the superscript number 1 represents Di et al. (2012).
↵c Data from the literature or calculated from reported fu and Rb (fub = fu/Rb). The superscript numbers represent the following: 1, fu from Chan et al. (2013); 2, fub referenced in Hallifax et al. (2010); 3, Aitio (1981); 4, Dixon and Warrander (1997).
↵d The superscript numbers represent the following references: 1, Chan et al. (2013); 2, Hinderling et al. (1974); or 3, not available (assumed to be 1).
↵e Represents results from Hallifax et al. (2010).
↵f Clh calculated using the well-stirred model (eq. 2) either with or without fub.
↵g Represents results from Di et al. (2012, 2013).
↵h The superscript numbers represent the following references: 1, Smith et al. (2012); 2, Blanchard et al. (2005) (scaled in vitro data using eq. 1).
↵i In vitro Clint value obtained from back-calculated in vitro scaled CLh (Chan et al., 2013) using the well-stirred model (modified eq. 3).
—, no data available.