TABLE 3

The k_el describing the elimination of TREO and S,S-EBDM from the rat plasma, brain and CSF with the corresponding t_1/2 values

Matrix	Rat Group	TREO		S,S-EBDM
Matrix	Rat Group	k_el	t_1/2	k_el	t_1/2
		h⁻¹	h	h⁻¹	h
Plasma	JR male	0.708 ± 0.046	0.98 ± 0.06	0.593 ± 0.090	1.17 ± 0.18
	JR female	0.587 ± 0.036	1.18 ± 0.07	0.511 ± 0.051	1.36 ± 0.14
	YAR male	1.012 ± 0.020	0.68 ± 0.01	1.039 ± 0.033	0.67 ± 0.02
	YAR female	1.066 ± 0.028	0.65 ± 0.02	0.969 ± 0.023	0.72 ± 0.02
Brain	JR male	0.274 ± 0.074	2.52 ± 0.68	0.451 ± 0.030	1.54 ± 0.11
	JR female	0.213 ± 0.003	3.26 ± 0.05	0.535 ± 0.029	1.30 ± 0.07
	YAR male	0.289 ± 0.0007	2.39 ± 0.006	1.106 ± 0.064	0.63 ± 0.04
	YAR female	0.331 ± 0.034	2,09 ± 0.21	0.881 ± 0.086	0.79 ± 0.08
CSF	YAR male	0.489 ± 0.010	1.42 ± 0.03	0.740 ± 0.050	0.94 ± 0.06
CSF	YAR female	0.528 ± 0.014	1.31 ± 0.03	0.735 ± 0.010	0.94 ± 0.01

Data are presented as the estimate ± S.E. The results of evaluation of the statistical difference in the k_el observed between the JR and YAR were as follows: plasma TREO: P = 0.0010 (male), 0.0009 (female); plasma S,S-EBDM: P = 0.0179 (male), 0.0022 (female); brain TREO: P = 0.8581 (male), 0.0731 (female); brain S,S-EBDM: P = 0.01332 (male), 0.0582 (female). There were no significant differences in the k_el of TREO and S,S-EBDM in plasma, brain and CSF between the male and female rats from the same age groups (P > 0.05).