Values for d determined by two methods and total Cmax inducer concentrations: 1) d factor obtained through GMFE error function and 2) d determined with rifampicin alone as calibrator for three experiments with the HepaRG cell line
The d factor value calculated with GMFE method is the average of the d values determined for each experiment (see Materials and Methods and Figure 1 for details).
| Method | HepaRG
Replicate 1 | HepaRG
Replicate 2 | HepaRG
Replicate 3 |
|---|---|---|---|
| d GMFE | 1.1 | 1.1 | 0.96 |
| d Rifampicin | 0.93 | 0.99 | 0.92 |