Observed protonated and deuteronated molecular ion and product ions for GDC-0623 and its metabolites in hydrogen/deuterium exchange experiments
| Analyte | Measured [M+H]+ | Exchangeable Hydrogens | Product Ions Observed | ||
|---|---|---|---|---|---|
| H2O | D2O | H2O | D2O | ||
| m/z | m/z | ||||
| GDC-0623 | 457.01624 | 461.04084 | 3 | 253, 380, 395 | 254, 381, 397 |
| M15 | 396.99603 | 401.02087 | 3 | 253, 380 | 254, 381 |
| M13 | 394.98026 | 396.99281 | 1 | 368 | 370 |
| M14 | 394.98030 | 396.99266 | 1 | 268, 347, 368 | 270, 348, 370 |