TABLE 7

Prediction of human pharmacokinetics and CL_renal for PF-06282999

Predicted Human Pharmacokinetics Parameter^{^a}	Rat	Dog	Monkey
CL_p (ml/min per kilogram)	8.6	1.8	3.4
Vd_ss (l/kg)	1.8	0.4	0.8
t_1/2 (h)	2.4	2.6	2.7
Total CL_renal (ml/min per kg)^{^b}	3.0	0.6	0.7

↵^a Observed pharmacokinetics in humans was as follows: CL_p = 1.8–2.1 ml/min per kilogram and Vd_ss = 0.65–0.78 l/kg (20–200 mg p.o. doses) obtained from the respective CL/F and V_z/F values normalized for F values corresponding to the percentage of dose eliminated in unchanged form in urine in a 24-hour period at the respective p.o. doses. Human t_1/2 was estimated to be 3.9–4.2 hours (20–200 mg p.o. doses) and was calculated using the equation 0.693 × Vd_ss/CL_p.
↵^b Observed total CL_renal in humans was1.8–2.1 ml/min per kilogram (20–200 mg p.o. doses).