TABLE 4

Median prediction error (MPE) and median absolute prediction error (MAPE) calculated using mPBPK-PD and full PBPK-PD models with nested TM and SFM following repeated i.v. administration (q2d ×3)

	Model Types
	TM						SFM
	mPBPK(TM)-PD		Full PBPK(TM)-PD		P Values^{^a}		mPBPK(SFM)-PD		Full PBPK(SFM)-PD		P Values^{^a}
Tissue and i.v. doses (pmol)	MPE	MAPE	MPE	MAPE	MPE	MAPE	MPE	MAPE	MPE	MAPE	MPE	MAPE
Plasma 2	365	365	359	359	<.001^{^b}	.001^{^b}	273	323	103	187	<.001^{^b}	.007^{^b}
Plasma 60	6314	6314	5659	5659	.062	.062	4512	4512	2946	2946	.008^{^b}	.008^{^b}
Plasma 120	1398	3991	339	4712	.100	.808	589	5763	57	4233	.010^{^b}	.040^{^b}
Kidney 120	20	113	17.5	17.5	.314	.028^{^b}	−3.52	66.5	4.60	13	.753	.028^{^b}
Liver 120	114	114	−43.4	43.4	.075	.046^{^b}	66.4	66.4	2.70	48.1	.028^{^b}	.028^{^b}
Ileum 120	667	667	365	365	.028^{^b}	.028^{^b}	374	374	7.70	132	.028^{^b}	.046^{^b}

↵^a The Wilcoxon matched pair test was performed to compare MPE and MAPE between the mPBPK-PD and full PBPK-PD models.
↵^b Differences between the mPBPK-PD and full PBPK-PD model (P < .05).