Cytotoxicity Value (IC50) | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Drug Alone | Drug + 1 nM TQR | Drug + 10 nM TQR | Drug + 100 nM TQR | Drug + 1 uM TQR | |||||||
Cell Line | Cytotoxic Drug | IC50 | RR | IC50 | RR | IC50 | RR | IC50 | RR | IC50 | RR |
nM | nM | nM | nM | nM | |||||||
KB-8-5-11 | Paclitaxel | 206 ± 51 | 52 | 228 ± 77 | 57 | 1 ± 0 | 0.25a | 1.5 ± 0.1 | 0.38a | 1 ± 0 | 0.25a |
KB-3-1 | Paclitaxel | 4 ± 0 | |||||||||
C3M | Paclitaxel | 8169 ± 844 | 190 | 7960 ± 2903 | 185 | 8368 ± 2056 | 195 | 375 ± 263 | 8.8b | 2.2 ± 0.1 | 0.05c |
3T3 | Paclitaxel | 43 ± 2 |
RR, resistance ratio (the quotient of the IC50 value of the resistant cell line to that of the parental line).
↵a P < 0.01 (α < 0.05, from initial IC50 value of resistant cell line) by Student’s two-tailed t test.
↵b P < 0.001 (α < 0.05, from initial IC50 value of resistant cell line) by Student’s two-tailed t test.
↵c P < 0.0001 (α < 0.05, from initial IC50 value of resistant cell line) by Student’s two-tailed t test.