TABLE 1

MicroRNAs are shown to modulate the expression of Phase I and II drug-metabolizing enzymes

EnzymemiRNAExperimental MethodsReferences
CYP1A1miR-892aReporter assay, mRNA and protein expression, and functional assayChoi et al., 2012
CYP1B1miR-27bCorrelation, reporter assay, protein expression, and functional assayTsuchiya et al., 2006
Protein and mRNA expressionChuturgoon et al., 2014
CYP2C8miR-103, miR-107Reporter assay, mRNA and protein expression, and correlation analysisZhang et al., 2012
CYP2C9miR-128-3pRNA electrophoresis mobility shift assay, reporter assay, mRNA & protein expression and correlationYu et al., 2015a
miR-130bReporter assay, protein expression, and functionRieger et al., 2015
miR-103 & miR-107Protein expressionZhang et al., 2012
CYP2C19miR-103 & miR-107Protein expressionZhang et al., 2012
miR-29a-3pRNA electrophoresis mobility shift assay, mRNA & protein expression, correlationYu et al., 2015c
CYP2E1miR-378Reporter assay, mRNA & protein expression, correlation, and functional assayMohri et al., 2010
miR-570Reporter assay, mRNA & protein expression, and correlation studyNakano et al., 2015
CYP2J2let-7bReporter assay, protein expression, and functional assayChen et al., 2012a
CYP3A4miR-27bReporter assay, mRNA and protein expression, and functional assayPan et al., 2009a; Li et al., 2014b
miR-34aCorrelationLamba et al., 2014
miR-577, -1, -532-3p, -627Correlation, reporter assayWei et al., 2014b
CYP24A1miR-125bReporter assay, mRNA & protein expression, and functional assayKomagata et al., 2009
UGT1A1/1A3/1A6miR-491-3pReporter assay, mRNA expression, correlation and/or activityDluzen et al., 2014
UGT2B15 & 2B17miR-376cReporter assay, mRNA expression and enzymatic activityWijayakumara et al., 2015
GSTπmiR-130bmRNA and protein expressionZong et al., 2014
SULT1A1miR-631Reporter assay, mRNA and protein expressionYu et al., 2010