Summary of kinetic data for DF and DF-AG for various human transporters in vitro
| Transporter | System | Km ± S.E. of the Parameter Estimate | |
|---|---|---|---|
| DF | DF-AG | ||
| µM | µM | ||
| OAT2 | HEK-293 Cells | 46.8 ± 12.2 | 8.6 ± 1.9 |
| OATP1B1 | HEK-293 Cells | —a | 34.0 ± 8.6 |
| OAT1 | HEK-293 Cells | —a | 60.2 ± 13.5 |
| OAT4 | HEK-293 Cells | —a | 103.9 ± 29.0 |
| OATP2B1 | HEK-293 Cells | —a | 104.6 ± 16.7 |
| OAT3 | HEK-293 Cells | —a | 114.1 ± 8.1 |
| MRP2 | Vesicles | —a | 145.0 ± 7.8b |
| BCRP | Vesicles | —a | 152.0 ± 54.9 |
| MRP3 | Vesicles | —a | 196.3 ± 58.0 |
| OATP1B3 | HEK-293 Cells | —a | — |