Metformin pharmacokinetic parameters from healthy individuals who were administered placebo or ondansetron
P < 0.05 was considered statistically significant.
| Parameters | Ondansetron | P value | |
|---|---|---|---|
| Absence | Presence | ||
| AUC0–24 h (µg⋅h/ml) | 15.2 ± 3.23 | 18.3 ± 5.05 | 0.006 |
| AUC0–∞ (µg⋅h/ml) | 15.7 ± 3.25 | 19.0 ± 5.20 | 0.004 |
| Cmax (µg/ml) | 2.28 ± 0.52 | 2.75 ± 0.64 | 0.014 |
| Tmax (h) | 2.63 ± 0.64 | 2.25 ± 0.79 | 0.158 |
| T1/2 (h) | 4.8 ± 0.9 | 5.5 ± 0.9 | 0.124 |
| V/F (l) | 394 ± 132 | 382 ± 115 | 0.797 |
| CL/F (l/h) | 56.6 ± 12.0 | 47.7 ± 12.0 | 0.005 |
| CLR (l/h) | 42.3 ± 12.9 | 27.2 ± 11.7 | 0.001 |
| fe.u 0–24 h (%) | 75.0 ± 15.9 | 57.8 ± 24.6 | 0.014 |
CL/F, oral clearance (clearance over oral bioavailability); V/F, oral volume of distribution (volume of distribution divided by oral bioavailability).