TABLE 4

Measures of predictive performance for simulations of pitavastatin disposition in four different batches of sandwich-cultured human hepatocytes (SCHHs)

Sample IDCompartmentAFEAAFE
SCHH UU113Medium1.101.12
Intracellular1.181.26
Intracellular + bile1.281.51
SCHH UU115Medium0.951.08
Intracellular0.851.19
Intracellular + bile0.941.37
SCHH UU112Medium0.901.11
Intracellular0.971.27
Intracellular + bile0.561.89
SCHH UU125Medium1.051.05
Intracellular0.811.33
Intracellular + bile0.821.34
  • AAFE, absolute average fold error; AFE, average fold error.