48-Hour bupropion and metabolite urinary excretion
Values denote means (n = 10 subjects) and 90% confidence intervals (CI).
| Analyte | 48-h Recovery, nmola Mean (90% CI) | % of Bupropion Dose Mean (90% CI) | ||
|---|---|---|---|---|
| Bupropion | 2172 | (1218–3125) | 0.60 | (0.3–0.86) |
| Hydroxybupropion | 2266 | (722–3811) | 0.67 | (0.21–1.12) |
| Threo-hydrobupropion | 9463 | (5384–13,542) | 5.24 | (2.98–7.51) |
| Erythro-hydrobupropion | 1953 | (894–3011) | 1.08 | (0.50–1.67) |
| (R,R)-hydroxybupropion glucuronide | 1275 | (732–1818) | 1.27 | (0.73–1.81) |
| (S,S)-hydroxybupropion glucuronide | 205 | (135–275) | 0.20 | (0.13–0.27) |
| EGLUC 1 | 275 | (179–372) | 0.26 | (0.17–0.36) |
| EGLUC 2 | 67 | (42–92) | 0.06 | (0.04–0.09) |
| (1R,2R)-hydrobupropion glucuronide | 591 | (325–857) | 0.57 | (0.31–0.82) |
| (1S,2S)-hydrobupropion glucuronide | 172 | (119–225) | 0.17 | (0.11–0.22) |
Erythro-hydrobupropion glucuronide (EGLUC).
↵a (R,R)- and (S,S)-hydroxybupropion glucuronides represent nmol equivalents relative to threo-hydrobupropion glucuronides with the same isomeric configuration.