Exposure of KAE609 and its metabolites in human plasma after an oral dose of 300 mg [14C] KAE609
Plasma samples were pooled according to the AUC pooling method. The pooled plasma samples were extracted and analyzed by LC-MS/MS for metabolic profiling.
| Subject ID | Exposure of KAE609 and Metabolites in Human Plasma | ||||||
|---|---|---|---|---|---|---|---|
| KAE609 | M14 | M16 | M18 | M23 | M23 | M23.5B | |
| ngEq⋅h/ml | |||||||
| 5101 | 92,191 | 11,703 | 1646 | 7679 | 18,843 | 18,843 | 3018 |
| 5102a | 115,775 | 2454 | ND | 14,162 | 5488 | 5488 | ND |
| 5103 | 61,945 | 4052 | 415 | 6931 | 12,515 | 12,515 | ND |
| 5104 | 72,620 | 3042 | ND | 6369 | 13,330 | 13,330 | ND |
| 5105 | 40,920 | ND | ND | 4016 | 3796 | 3796 | ND |
| 5106 | 66,537 | 4162 | ND | 7513 | 16,176 | 16,176 | ND |
| Mean | 74,998 | 4236 | 344 | 7778 | 11,691 | 11,691 | 503 |
| SD | 25,951 | 3958 | 659 | 3397 | 5924 | 5924 | 1232 |
| Meanb | 75.8 | 3.79 | 0.28 | 7.82 | 11.9 | 11.9 | 0.37 |
| SD | 6.81 | 2.96 | 0.50 | 1.56 | 4.95 | 4.95 | 0.91 |
ND, not detectable (zero was used for calculation of mean values).
↵a Plasma samples were pooled from all subjects (except 1502) from 0 to 120 hours postdose, and plasma samples from subject 1502 were pooled from 0 to 144 hours.
↵b Mean values represented as the percentage of total radioactivity in human plasma.