Fluorinated analogs of four drugs generated by biosynthesis of hydroxyl metabolites and deoxyfluorination by DAST
| Parent Drug | Biosynthesis Enzyme | Fluorinated Product | Stock Concentration Obtained |
|---|---|---|---|
| mM | |||
| Midazolam | CYP3A5 | 1′-Fluoromidazolam | 1.35 |
| Ramelteon | CYP1A2 | 2-Fluororamelteon | 0.26 |
| Celecoxib | CYP2C9 | 4′-Fluorocelecoxib | 2.32 |
| Risperidone | CYP2D6 | 9-Fluororisperidone | 0.96 |